Enzyme Development Scientist
Location Jupiter, FL
Reports To: CSTO
About the Job
The Enzyme Development team is responsible for creating new enzyme constructs, including engineering novel gene sequences, cloning genes into microbial production strains, and optimizing host strain growth conditions to maximize production of the target gene.
Our team is tasked with finding creative ways to deliver enzyme producing organisms that push the production capacity of our targets to the biological limit.
As part of this team, you will work closely with the team lead to prioritize and execute new enzyme development projects, working in collaboration with external contractors, the protein purification team, Quality Control, and Client Services teams in a rapidly iterating feedback loop to deliver new product constructs to the purification team on time, and to the desired specifications.
You’re highly experienced in cloning and expressing genes in multiple microbial systems, including pro-and eukaryotes, and have a clear sense of how to arrange your work in order to meet tight deadlines. You understand protein engineering and may have used rational design or directed evolution to enhance the function of an enzyme. You’re detail oriented and can work on several competing projects simultaneously. You can communicate results and next steps efficiently, and foster collaboration around the achievement of a common goal. You’ll be the main liaison between Alphazyme and our external development partners and will play a key role in on-boarding new projects with Client Services.
The products you will create are the tools which our Clients will use to read and write nucleic acids in the fields of medicine, life science research, energy production, data storage, and other vast applied markets. Your work will support Alphazyme’s mission to be the partner of choice for firms who leverage the power of genomics to solve the most complex, urgent challenges facing humanity today.
- Work with Client Services to define new enzyme specifications
- Develop and implement cloning, host selection, and expression optimization strategies to meet design criteria
- Create and implement sequence engineering strategies to support NPIs
- Collaborate with scientific departments to communicate results, advance projects
- Manage external development partners to ensure the timely and accurate delivery of work-in-progress materials
- Document enzyme development steps/optimization and author final design history
- Train other enzyme development team members as needed
Alphazyme was founded in 2018 by experts in the field of enzyme development and production with a track record of success and a passion for supporting innovators in molecular science. Our mission is to be the world’s premier partner for custom, industrial-scale molecular biology enzymes. We partner with the manufacturers of nucleic acid therapies and detection platforms to develop and produce affordable, reliable enzymes which meet the specifications of the rapidly expanding market for custom DNA and RNA molecules, genomic medicines and genetic tests. Consistent quality, scalable production, and compatibility with regulatory requirements are the hallmarks of our business.