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Fermentation Development Scientist

Location: Jupiter, FL
Reports To: CSTO
Status: Exempt


Position Summary
Reporting to the CSTO, the Fermentation Development Scientist executes the Company’s enzyme development projects according to customer-driven timelines and internal prioritization. We are seeking a highly motivated Scientist to join the Process Development Team in pursuit of optimizing upstream processes. As an integral member of the team, the successful candidate will focus on developing and optimizing fermentation/upstream processes for the manufacturing of protein enzyme products in compliance with the FDA’s 21 CFR 211/820 design control requirements. She/he is an experienced scientist with outstanding protein expression, and strain optimization skills in both bacterial and eukaryotic systems. Alphazyme maintains a commitment to Quality and a culture of continuous improvement, and the Scientist shall periodically recommend efficiency improvements to the Company’s development processes to management.

Job performance will involve a variety of activities including:

  • Leading the Bioreactor & Fermentation Development team in the set-up, operation, and associated analysis of mammalian cell culture and/or microbial bioreactor processes
  • General operations such as bioreactor building/sterilization, cleanup and turnover of bioreactors to maintain a set run schedule Sampling including cell count and metabolite analysis
  • Collaborate with multiple areas to execute data mining efforts in support of long term project management
  • Maintain records and test results following good manufacturing practices (GMP) Work independently and efficiently
  • Document work clearly and perform procedures accurately Communicate effectively with client staff members
  • Work will include periodic evening and/or early morning weekday hours as well as periodic weekend hours
  • Participate in new technology evaluation, development, and implementation
  • Document, compile, and analyze experimental data
  • Communicate results at team meetings, contribute to project and experiment planning
  • Develop and maintain protocols, operational processes, and safety best practices
  • Follow safety, quality control and quality assurance procedures
  • Interface and productively collaborate with members of cross-organizational teams, including external partners and customers
  • Contribute to development projects including planning, strategic direction, experimental design, data analysis and interpretation
  • Research new equipment, technologies that contribute to platform improvement
  • Train others on procedures, operations, new technologies, methods and mentor new scientists
  • Identify technical issues, troubleshooting, solve problems and achieve clear resolution
  • Provide effective management for planning, coordinating and executing tasks and projects in a given time frame
  • Maintain laboratory documentation in accordance with applicable scientific, regulatory, and intellectual property requirements
  • Prepare technical reports and lead project reviews
  • Work will include periodic evening and/or early morning weekday hours as well as periodic weekend hours
  • Other duties as needed


  • Advanced degree in Microbiology, Biochemistry, Chemical Engineering or related field required
  • Minimum 5 years of hands-on experience in fermentation development
  • Proven experience in developing batch and fed-batch fermentation processes
  • Familiarity with upstream instrumentation, equipment and software
  • Strong working knowledge of bacterial and fungal physiology and genetics
  • Ability to manage and prioritize multiple projects within a fast-paced environment
  • Exceptional attention to detail and passion for problem-solving
  • Ability to work a flexible schedule, as required, to meet development and maintenance scheduling needs
  • Excellent organizational, interpersonal and communication skills
  • Team player, results oriented and able to work in multidisciplinary teams
  • Creativity, strong problem solving and critical thinking skills
  • Computer skills (Proficiency with MS Word, PowerPoint, Excel, and Access is expected)
  • Experience in a Good Manufacturing Practice (GMP) or ISO 13485 environment is desired
  • Ability to organize tasks and work independently; ability to communicate effectively orally and in writing; ability to use science literature and reference texts; ability to keep accurate records; ability to work safely


  • Minimum Bachelor’s degree with 5 years of industrial experience


About Alphazyme
Alphazyme was founded in 2018 by experts in the field of enzyme development and production with a track record of success and a passion for supporting innovators in molecular science. Our mission is to be the world’s premier partner for custom, industrial-scale molecular biology enzymes. We partner with the manufacturers of nucleic acid therapies and detection platforms to develop and produce affordable, reliable enzymes which meet the specifications of the rapidly expanding market for custom DNA and RNA molecules, genomic medicines and genetic tests. Consistent quality, scalable production, and compatibility with regulatory requirements are the hallmarks of our business.

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Please contact us to discuss your custom project.